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人類疾病動物模型
心臟病模型
Modeling cardiovascular disease in the zebrafish. Trends Cardiovasc Med. 2008 18:150-155.
Zebrafish cardiac enhancer trap lines: new tools for in vivo studies of cardiovascular development and disease. Dev Dyn. 2010 239:914-926.
肥胖症模型
Creation of a genetic model of obesity in a teleost. FASEB J. 2007 21:2042-2049.
Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 2012 7:e36474.
老化模型
Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging. G3 (Bethesda). 2011 1:531-538.
神經退化性疾病
Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio. PLoS One. 2012 7:e42117.
Transgenic zebrafish model of neurodegeneration. J Neurosci Res. 2002 70:734-745.
癌症疾病模型
Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish. Adv Hematol. 2012:478164.
Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future Oncol. 2012 8:21-28.
環境汙染檢測
檢測
重金屬汙染
Detection of mercury in aquatic environments using EPRE reporter zebrafish. Mar Biotechnol (NY). 2008 10:750-757.
Developmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line. Environ Health Perspect. 2002 110:1041-1046.
Transgenic zebrafish as sentinels for aquatic pollution.
Ann N Y Acad Sci. 2000 919:133-147.
檢測環境賀爾蒙
汙染
Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals.
Toxicol Appl Pharmacol. 2012 262:149-155.
Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos. PLoS One. 2012 7:e36069.
Visualization of estrogen receptor transcriptional activation in zebrafish. Endocrinology. 2011 152:2690-2703.
Generation of a fluorescent transgenic zebrafish for detection of environmental estrogens. Aquat Toxicol. 2010 96:53-61.
檢測戴奧辛
屬汙染
Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio). Environ Health Perspect. 2001 109:845-849.
Oxidative stress in zebrafish cells: potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. Sci Total Environ. 2001 274:183-196.
發育生物學
檢測細胞凋亡與自噬
Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: a new in vivo model for investigation of liver autophagy. Biochem Biophys Res Commun. 2012 422:268-273.
檢測細胞週期
Illuminating cell-cycle progression in the developing zebrafish embryo. Proc Natl Acad Sci U S A. 2009 106:20812-20817.
Production of transgenic medaka fish carrying fluorescent nuclei and chromosomes. Zoolog Sci. 2009 26:9-16.
檢測器官發育
435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish.
Dev Dyn. 2003 227:347-356.
Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish.Dev Dyn. 2003 228:30-40.
A cyp19a1b-gfp (aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells. Genesis. 2009 47:67-73.
藥物篩選模型
篩選心臟病相關藥物
Validation of visualized transgenic zebrafish as a high throughput model to assay bradycardia related cardio toxicity risk candidates. J Appl Toxicol. 2012 32:834-842.
In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res. 2012 93:463-470.
篩選抗血管新生藥物
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res. 2007 67:11386-11392.
A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol. 2007 307:29-42.
篩選抗腫瘤藥物
An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening.1. Dis Model Mech. 2012 5:63-72.
One step forward: the use of transgenic zebrafish tumor model in drug screens. Birth Defects Res C Embryo Today. 2011 93:173-181.
Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds. Transgenic Res. 2009 18:855-864.